Regenerative cells. - Stem cells-Japan's advanced medical brigade サービス co., LTD-

Every day our bodies lose more and more of their vital cells,
Stem cells, by proliferating and differentiating,
Cells that metabolically damage cells and supplement apoptosis.
At the same time, stem cells can transmit signals,
Activates aging and weakening cells in the body.

What are stem cells?

幹細胞とは?

All the cells inside our bodies, including those that make up tissues like skin or blood, have a very short life span. In order for all tissues to be able to replace smoothly and maintain the good functioning of the body, new cells must be constantly replenished to replace the dying cells. And the cells that have this ability are called stem cells.

What is regenerative medicine?

再生医療とは?

Regenerative medicine is a cutting-edge medical treatment that uses stem cells to repair tissue or restore organ defects or dysfunction. Stem cells can be divided into pluripotent stem cells, which are represented by iPS cells, and somatic stem cells, which are represented by mesenchymal stem cells (MSC).

On the difference between iPS cells and MSC cells

Stem cell therapy

幹細胞治療

Through the process of stem cell blending, in vitro culture, directional induction, and even gene modification, new, normal or even younger cells, tissues or organs are bred in vitro, and finally through the transplantation of cells or tissues or organs to achieve the treatment of clinical diseases. Stem cell technology's most notable effect: the ability to create a new, normal or even younger kind of cell, tissue or organ.

The application of stem cell therapy

幹細胞治療の応用

1. Repair damage to specific organs or tissues, restore or enhance their function

2. Restore, rebuild and consolidate the balance of the body's healthy system

3. Effective prevention and treatment of aging diseases

Characteristics of stem cell therapy

幹細胞治療の特徴

1. It comes from one's own cells

2. There are no medical ethics issues

3. Genetic manipulation is not required

4. No carcinogenesis has been reported

5. It has multiple differentiation functions

Principles of MSC mesenchymal stem cells

MSCの原理

Effects of systemic immune system delivery - Lymphoid tissue/injury site

By injecting mesenchymal stem cells throughout the body,
can induce terminal (endocrine) effects, including cell-mediated actions, as well as local (paracrine) effects.

1) Vascular endothelial growth factor (VEGF), insulin growth factor 1 (IGF-1), single bulb chemical inducer protein 1 (MCP1), basic fibroblast proliferation factor (bFGF), IL6
2) Stem cell proliferation and differentiation: stem cell factor (SCF), leukemia blocking factor (LIF), MCSF, SDF1, angiopoietin 1, activin A
3) Obstruction of fibrosis: stem cell growth factor (HGF), bFGF, ADM
4) Obstruction of paracrine effect: the immune-mediated effects of VEGF, HGF, IGF1, TGFβ, bFGF, GM CSF, activin A and platelet 1 mainly include 5) -8)
5) T cell and B cell inhibition: leukocyte antigens G5, HGF, iNOS, IDO, PGE2, bFGF, TGFβ
6) Differentiation and proliferation effects were achieved through TGFβ discovery of controlled T cells
7) Inhibit NK cells through IDO, PGE2 and TGFβ secretion
8) Inhibit dendritic cell maturation through secretion of PGE2

Stem Cell Therapy - The role of stem cells in the field of disease

疾患別治療法

anti-aging

Renal insufficiency/diabetes

Treatment of deformable knee arthritis

Hair follicle

Parkinson's disease

Stem cell culture laboratory facilities

細胞培養ラボの設備

The cells were incubated under strict sanitary control: clean air at ISO level 5 (level 100) was supplied to the laboratory operating station to keep the culture environment clean. The Cell Conditioning Facility (CPC) is used to extremely high standards for cell proliferation and management, keeping the number of tiny particles to a minimum and ensuring that the laboratory remains sterile at all times. And, in order to maintain a high level of safety, we conduct careful bacterial screening when the cells are placed in storage. In order to prevent different cell samples from being mistaken, Barcode is used for management, and a unique operation management system including all cell culture processes is constructed to implement strict quality management.

Cell Culture Facility (CPC)

Cell culture video

細胞培養ビデオ

Stem cell therapy

幹細胞治療の流れ

Consult and provide relevant health information

Make an appointment and charge for service

Go to Japan

Initial diagnosis

pay

Cell extraction

Cell culture

The stem cells were injected into the hospital

End of treatment

I will return three months later

Risks of stem cell therapy

幹細胞治療のリスク

Background:

Mesenchymal stem cells (MSC) are widely used in various clinical and medical experiments. Although there are high expectations for the efficacy of treating major diseases through stem cells, there is no guarantee of its safety. We conducted systematic clinical trials to comprehensively evaluate the safety of MSC.

Methods and results:

We looked at MEDLINE, EMBASE, and CENTRAL (through June 2011). We conducted clinical trials of vascular delivery (intravenously or intravenously) of MSC in adults and a mixture of adults and children. Studies that differentiated MSC and other cell types were excluded. Our main evaluation items included acute side effects (acute injection toxicity, fever), visceral complications, infections, and long-term adverse events (death and malignancy). We looked at 2,347 papers and examined 36 studies. The 1,012 participants included patients treated for ischemic stroke, Crohn's disease, myocarditis, myocardial infarction, graft-versus-host disease, and healthy individuals. A total of eight studies were randomized comparison trials (RCTS) involving 321 participants. In RCTS, we found no association between acute injection toxicity, organogenic comorbidity, infection, death, or malignancy. MSC was significantly associated with transient fever.

Conclusion:

At this stage of clinical trials, MSC therapy can be described as safe. However, to further ensure the safety of MSC, we will strictly report adverse events and conduct larger clinical trials.

Qualifications owned by the partner organization

再生医療計画厚労省受理

GCR certification

Committee on Specific Certified Regenerative Medicine

Obtain ISO 9001

Facial fat stem cell injection program approved

Application registration for manufacture of specific cell processing material

Dental disease stem cell filling program acceptance letter

Knee joint stem cell injection program in hand

Letter of acceptance for venous infusion of stem cells with vein sclerosis program

Letter of acceptance for NK cell intravenous injection plan

Letter of acceptance for the non-facial stem cell culture Program

Subcutaneous stem cell injection program acceptance letter

Q&A

よくあるご質問

How long will it take to feel the effects?

About three to six months.

Were there any dietary restrictions before the blood was drawn?

No special dietary restrictions are required.

Where do stem cells exist?

Cells are found throughout the body. Adipose stem cells account for the largest proportion, but advances in cell culture techniques have made it possible for skin and subcutaneous fat to produce as many or more stem cells. Because liposuction is psychologically difficult, stem cells were taken from skin and subcutaneous fat.

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